Anaplastic Large Cell Lymphoma, ALK-Negative: A Rare Case with Histopathological and Immunohistochemical Features

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Published: Oct 9, 2025
DOI: https://doi.org/10.52600/2763-583X.bjcr.2026.6.1.bjcr124
Keywords:
Lymphoma, Large-Cell, Anaplastic, Pathology, Differential Diagnosis

Main Article Content

Bilal Ramez Bakri
Biomega Laboratory
https://orcid.org/0009-0003-4924-0646
Camila Machado Baldavira
Department of Pathology, Faculty of Medicine, University of São Paulo
https://orcid.org/0000-0002-5364-7305
William Marques Pirani
Biomega Laboratory
Alexandre Ab’Saber
Department of Pathology, Faculty of Medicine, University of São Paulo
Vera Luiza Capelozzi
Department of Pathology, Faculty of Medicine, University of São Paulo
https://orcid.org/0000-0001-9732-5853

Abstract

We report a case of anaplastic large cell lymphoma (ALCL), ALK-negative, diagnosed in a 27-year-old patient presenting with diffuse lymphadenopathy and constitutional symptoms. Histopathological examination revealed sheets of large pleomorphic lymphoid cells, and immunohistochemistry demonstrated CD30 positivity with ALK negativity. This case highlights the diagnostic and therapeutic challenges associated with this rare subtype of T-cell lymphoma and contributes to the growing body of literature on ALCL ALK-negative.

Article Details

How to Cite
Bakri, B. R., Baldavira, C. M., Pirani, W. M., Ab’Saber, A., & Capelozzi, V. L. (2025). Anaplastic Large Cell Lymphoma, ALK-Negative: A Rare Case with Histopathological and Immunohistochemical Features. Brazilian Journal of Case Reports, 6(1), bjcr124. https://doi.org/10.52600/2763-583X.bjcr.2026.6.1.bjcr124
Issue
Vol. 6 No. 1 (2026): January/December - 2026
Section
Clinical Case Reports
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Author Biographies

Bilal Ramez Bakri, Biomega Laboratory

Biomega Laboratory, Barueri, São Paulo, Brazil.

Camila Machado Baldavira, Department of Pathology, Faculty of Medicine, University of São Paulo

Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.

William Marques Pirani, Biomega Laboratory

Biomega Laboratory, Barueri, São Paulo, Brazil.

Alexandre Ab’Saber, Department of Pathology, Faculty of Medicine, University of São Paulo

Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.

Vera Luiza Capelozzi, Department of Pathology, Faculty of Medicine, University of São Paulo

Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.

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