Endocrinopatias múltiplas adquiridas pelo uso de um inibidor de checkpoint - Pembrolizumab: Um Relato de Caso
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Resumo
A imunoterapia com inibidores de checkpoint (ICIs) tem sido cada vez mais empregada no tratamento de muitas neoplasias malignas, e as endocrinopatias são um dos efeitos colaterais mais frequentes. Este relato de caso descreve um homem de 70 anos que enfrentou várias endocrinopatias (hipotireoidismo primário, insuficiência adrenal secundária e diabetes mellitus) após o início da imunoterapia com um ICI (pembrolizumabe) para o tratamento de câncer de bexiga urotelial. Discutimos a prevalência, fisiopatologia, triagem e diagnóstico de cada uma dessas anomalias. Os clínicos precisam estar cientes dessas complicações endócrinas da terapia com ICIs e estar preparados para o diagnóstico precoce e manejo adequado.
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